A comparative study of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) blood levels and peripheral blood parasitemia as parameters of disease severity in individuals with imported falciparum malaria

Abstract Background In falciparum malaria the total parasite biomass can be estimated by blood levels of histidine-rich protein 2 (PfHRP2), a Plasmodium falciparum-specific protein, which has been widely studied in malaria-endemic regions. This study investigates usefulness PfHRP2 as marker for disease severity imported malaria. Methods A retrospective cohort analysis was done 145 patients with Associations between PfHRP2, and classic parameters were examined statistical analyses. Patients different travel purposes two groups: visiting friends relatives (VFRs) other (mainly tourists). Results High clearly associated severity. VFRs status showed to an independent determinant protecting against severe At similar had significantly lower peripheral parasitemia compared patients. Conclusion Our confirms association malaria, but proper interpretation travellers, possible presence pre-existing acquired anti-malarial immunity should taken into account correlation differed purposes.